With two-thirds of ballots counted, results from the Greek referendum show voters decisively rejecting the terms of an international bailout.
Figures published by the interior ministry showed 61% of those whose ballots had been counted voting "No", against 39% voting "Yes".
Greece's governing Syriza party campaigned for a "No", saying the bailout terms were humiliating.
The "Yes" campaign warned this could see Greece ejected from the eurozone.
Some European officials had also said that a "No" would be seen as an outright rejection of talks with creditors.
But Greek government officials have insisted that a "No" vote would strengthen their hand and that they could rapidly strike a deal for fresh funding in resumed negotiations.
Greek banks will reopen by Tuesday, they say.
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Reacting to the result, Greek Finance Minister Yanis Varoufakis called it "a big yes to a democratic Europe".
He said Greece would be "positive" in negotiations with its creditors.
Euclid Tsakalotos, Greece's deputy foreign minister, told Star TV that two developments would allow Greece to pursue "a solution that is financially viable".
"Firstly, the government now has a new popular mandate and the second is the latest [International Monetary Fund] report which says that the Greek debt is unsustainable."
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